In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1120, No. 1 ( 2007-12), p. 144-151
Kurzfassung:
Abstract : The transcription factor Ets‐variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self‐renewal, as the targeted deletion of the Etv5 gene in mice ( Etv5 −/− ) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild‐type (WT) and Etv5 −/− testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5 −/− recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood–testis barrier (Sertoli–Sertoli tight junctional complex) is abnormal in the Etv5 −/− mouse.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1411.005
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2007
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
