In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. 10575-10575
Abstract:
10575 Background: To evaluate the incidences and trends of social determinant risk factor-associated cancers in the United States from 2001 to 2018. Methods: Social determinant risk factor-associated cancers, as classified by the CDC, were included: obesity, alcohol, tobacco, physical inactivity, and human papillomavirus (HPV). Data was obtained from the United States Cancer Statistics program from 2001-2018. SEER*Stat 8.3.9.2 and Joinpoint regression program 4.9.0.0 were used to calculate incidences and trends of cancers per 100,000. The age-adjusted incidence (AAI) was adjusted by the US 2000 standard population. Results: Over the 17-year study period, a total of 28,175,859 cancers were identified. Of these, 51.4% developed in men and 48.6% in women. Over 65.8% were risk factor-associated cancers and 34.2% were unrelated to these factors. Of note, over 60.1% of risk factor-related cancers developed in women compared to 39.9% in men. Although the incidence of risk factor associated cancers did not significantly change at 413.2/100,000 in women, this incidence decreased by 1.15% annually ( P 〈 0.001). The age-specific incidences decreased in older ( 〉 50 years) men and women. Of the younger (20-45 years) group, these risk factor-associated cancers increased from 91.5 to 97.3/100,000 with an annual increase of 0.4% ( P 〈 0.001) in younger women; there was no change for younger men on trend analyses over the study period. Conclusions: Over 65% of cancers in the US were associated with social determinants of health. There is a disproportionate burden of risk factor-associated cancers in women with increasing rates in younger age groups. Further research is needed to better understand the rationale of these important trends.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2022.40.16_suppl.10575
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2022
detail.hit.zdb_id:
2005181-5
