In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. e17515-e17515
Kurzfassung:
e17515 Background: The development of deep postovariectomy disorders in young women with cervical and breast cancers is of extreme concern. They are associated with the suppression of the hypothalamic-pituitary-gonadal axis of regulation, estrogen involution, a sharp depression of the psycho-emotional state, and social distancing. In fact, these postovariectomy syndrome (POES) events are associated with low-reactivity stress syndrome. Our purpose included the transition of dominant stress into archetypes of anti-stress adaptive reactions under the influence of programmable exponential dose regimens of xenon-oxygen therapy (XOT) in the early period after the removal of the female reproductive organs. Methods: 123 patients of reproductive age diagnosed with cervical cancer pT 1 B 2 N 0 M 0 and 24 patients with hormone-positive breast cancer pT 2 N 1 M 0 and concomitant gynecological pathology underwent hysterectomy with oophorectomy and developed POES. All patients received a cycle (5 procedures) of low-dose inhalation XOT. The therapy consisted in a gradual increase in the percentage of xenon in the inhaled xenon-oxygen mixture with a reciprocal decrease in exposure time, an exponential regimen in the concentration range from 12–14% to 20–24% and exposure from 25 to 10 minutes. Blood levels of FSH, LH, estradiol, progesterone, and testosterone were measured by RIA (Immunotech, Czech Republic) before and after XOT. The psycho-emotional status was assessed by the generally accepted quality of life scales for cancer patients MOS-SF-36 and ESAS, the type of adaptive reactions was identified by Garkavi using the analysis of Schilling's leukogram, the severity of POES was determined by the menopausal index (MMI). Results: The POES manifestation and the dominance of acute stress were due to the inversion of hormonal metabolism - a decrease in the level of estradiol 487.3±52.4 and progesterone 1.8±0.1 relative to the initial levels 1017.9±83.4 nmol/L and 11.8±0.7 nmol/L, respectively, with an increase in FSH by 5.8 times, and LH by 2.4 times (p 〈 0.05). An accompanying XOT resulted in a significant MMI decrease (p 〈 0.05), training and calm activation reactions prevailed in 80% cases with harmonious changes in the regulation of hormonal processes and a clear regression of the acute estrogen deficiency (elevation of estradiol levels to 751.4±61.4 nmol/L and a decrease in FSH and LH by 1.5 and 2.1 times, respectively (p 〈 0.05)). MOS-SF-36 and ESAS assessment showed a significant decrease in pathological symptoms. Conclusions: XOT in the early postoperative period in cancer patients of the reproductive age with POES normalized their hormonal status, corrected functional disorders and improved their quality of life.
Materialart:
Online-Ressource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2022.40.16_suppl.e17515
Sprache:
Englisch
Verlag:
American Society of Clinical Oncology (ASCO)
Publikationsdatum:
2022
ZDB Id:
2005181-5
