In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. 10065-10065
Abstract:
10065 Background: To reporton the activity of radiotherapy (RT) in a retrospective series of solitary fibrous tumors (SFT)/hemagiopericytoma (HCP), a rare soft tissue sarcoma subtype whose sensitivity to RT is poorly known. Methods: We retrospectively reviewed all patients with a diagnosis of SFT/HCP whom we saw from 2005 to 2011, focusing on cases treated with RT in neoadjuvant, adjuvant, exclusive, palliative settings. Patients who received concomitant chemotherapy were excluded. We confirmed diagnosis by review in all cases. We evaluated the overall response rate (RR) by RECIST. Results: Nineteen patients were identified (males = 9, females = 10; median age = 61 years, range 39-85; site of primary= 6 meninges, 4 pleura, 3 pelvis, 3 retroperitoneum, 2 limbs, 1 abdominal wall; site of RT= 5 bone and soft tissue, 5 pelvis, 3 soft tissue, 2 meninges, 2 retroperitoneum, 1 abdominal wall, 1 pleura; reason for RT= 3 neoadjuvant, 2 adjuvant, 2 exclusive and 12 palliative setting). Median RT dose was 42 Gy (range 12-60). Seventeen of 19 pts are evaluable for response (2 adjuvant). The RR was: 29% (4 pts) partial response, 65% (12 pts) stable disease (SD), 6% (1 pt) progressive disease (PD). All patients treated with neoadjuvant RT had a RECIST SD as best response to pre-operative treatment with evidence of pathologic response in 2 of 3 cases. Conclusions: Contrary to what is widely thought,this retrospective analysis suggests that SFT/HCP is sensitive to radiation therapy. Prospective studies are needed.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2012.30.15_suppl.10065
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2012
detail.hit.zdb_id:
2005181-5
