In:
Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. 4 ( 1999-03-01), p. 849-849
Abstract:
Article abstract The authors found a strong geographic cluster of spinocerebellar ataxia type 6 (SCA6) families in the Northrhine–Westfalia area, suggesting a founder effect in the German SCA6 population. Genotyping with DNA markers linked to the CACNL1A4 gene on chromosome 19p13 revealed a common haplotype and shared allelic characteristics in the majority of German families. The observed founder effect may be related to the relative meiotic stability of CAG repeats in this type of autosomal dominant cerebellar ataxia.
Type of Medium:
Online Resource
ISSN:
0028-3878
,
1526-632X
DOI:
10.1212/WNL.52.4.849
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
1999