In:
Development, The Company of Biologists, Vol. 127, No. 15 ( 2000-08-01), p. 3361-3371
Kurzfassung:
An essential aspect of a neuron’s identity is the pattern of its axonal projections. In C. elegans, axons extend either longitudinally or circumferentially in response to distinct molecular cues, some of which have been identified. It is currently unclear, however, how the differential capacity to respond to these cues is transcriptionally implemented in distinct neuronal subtypes. Here, we characterise a C. elegans paired-like homeobox gene, CePhox2/ceh-17, expressed in five head neurons, ALA and the 4 SIAs, all of which project axons towards the tail along the lateral and sublateral cords. Abrogation of ceh-17 function, while leaving intact many phenotypic traits of these neurons, disrupts their antero-posterior axonal elongation beyond the mid-body region. Conversely, ectopic expression of ceh-17 in the mechanoreceptors, several of which are known to pioneer their tract, leads to exaggerated longitudinal axonal outgrowth. Thus, ceh-17 is a novel gene involved in fasciculation-independent longitudinal axonal navigation.
Materialart:
Online-Ressource
ISSN:
0950-1991
,
1477-9129
DOI:
10.1242/dev.127.15.3361
Sprache:
Englisch
Verlag:
The Company of Biologists
Publikationsdatum:
2000
ZDB Id:
2007916-3
SSG:
12
