In:
Development, The Company of Biologists, Vol. 149, No. 8 ( 2022-04-15)
Kurzfassung:
Maintenance of a healthy pregnancy is reliant on a successful balance between the fetal and maternal immune systems. Although the maternal mechanisms responsible have been well studied, those used by the fetal immune system remain poorly understood. Using suspension mass cytometry and various imaging modalities, we report a complex immune system within the mid-gestation (17-23 weeks) human placental villi (PV). Consistent with recent reports in other fetal organs, T cells with memory phenotypes, although rare in abundance, were detected within the PV tissue and vasculature. Moreover, we determined that T cells isolated from PV samples may be more proliferative after T cell receptor stimulation than adult T cells at baseline. Collectively, we identified multiple subtypes of fetal immune cells within the PV and specifically highlight the enhanced proliferative capacity of fetal PV T cells.
Materialart:
Online-Ressource
ISSN:
0950-1991
,
1477-9129
Sprache:
Englisch
Verlag:
The Company of Biologists
Publikationsdatum:
2022
ZDB Id:
2007916-3
SSG:
12