In:
Journal of Cell Science, The Company of Biologists
Kurzfassung:
Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial for producing fertilizable oocytes competent to support embryogenesis. However, how oocyte-derived signaling regulates these essential processes remains largely undefined. Here, we demonstrated that oocyte-derived paracrine factors, particularly GDF9 and GDF9:BMP15 heterodimer, promote the development and survival of cumulus-oocyte complexes (COCs) partly by suppressing the expression of Ddit4l, a negative regulator of MTOR, and enabling the activation of MTOR signaling in cumulus cells. Cumulus cells expressed less Ddit4l mRNA and protein than mural granulosa cells, which is in striking contrast to the expression of phosphorylated RPS6 (a major downstream effector of MTOR). Knockdown of Ddit4l activated MTOR signaling in cumulus cells, whereas inhibition of MTOR in COCs compromised oocyte developmental competence and cumulus cell survival, with the latter likely attributable to specific changes of a subset of transcripts in the transcriptome of COCs. Therefore, oocyte suppression of Ddit4l expression allows for MTOR activation in cumulus cells, and this oocyte-dependent activation of MTOR signaling in cumulus cells controls the development and survival of COCs.
Materialart:
Online-Ressource
ISSN:
1477-9137
,
0021-9533
Sprache:
Englisch
Verlag:
The Company of Biologists
Publikationsdatum:
2016
ZDB Id:
219171-4
ZDB Id:
1483099-1
SSG:
12