In:
Journal of Bone and Mineral Research, Wiley, Vol. 20, No. 2 ( 2005-02), p. 350-353
Abstract:
A 45‐year‐old woman presented with recent onset of left‐sided chest pain. On clinical examination, these symptoms seemed to be strictly localized to a region that was marked by a long‐standing cutaneous erythematous lesion. Laboratory results showed no gross abnormalities. Radiological imaging including conventional X‐ray, MRI scans, and 3D CT reconstruction of the rib cage revealed circumscript destruction of the left lateral ribs 9–11. Histological analysis of a rib biopsy showed angiomatous hypervascularization and intracortical fibrosis. In keeping with these findings, the patient's condition was diagnosed as Gorham‐Stout disease, a rare condition with localized, often unilateral, bone destruction. Monotherapy with bisphosphonates (pamidronate 30 mg IV every 3 months) was initiated, leading to rapid disappearance of local pain. Follow‐up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction.
Type of Medium:
Online Resource
ISSN:
0884-0431
,
1523-4681
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2008867-X
