In:
Journal of Bone and Mineral Research, Wiley, Vol. 13, No. 8 ( 1998-08), p. 1328-1336
Abstract:
A dual positron emission tomography (PET) tracer study with [ 18 F]fluoride and the freely diffusible tracer [ 15 O]H 2 O was performed to measure the capillary transport of [ 18 F]fluoride and to evaluate the potential of [ 18 F]fluoride ion PET to quantitate bone blood flow. Under the condition of a high predictable single‐pass extraction fraction (E F ) for [ 18 F]fluoride, the [ 18 F]fluoride ion influx transport constant (K 1F ), derived from kinetic [ 18 F] fluoride ion PET measurements, can be used to estimate bone blood flow. Bone blood flow was measured in vertebral bodies by dynamic [ 15 O]H 2 O PET during continuous ventilation with N 2 O, O 2 , and Isoflurane (FiO 2 = 0.3) in seven adult mini pigs, followed by dynamic [ 18 F]fluoride ion PET. The mean blood flow measured by [ 15 O]H 2 O (Flow O ) was 0.145 ± 0.047 ml·minute –1 ·ml –1 and the mean K 1F was 0.118 ± 0.031 ml·minute –1 ·ml –1 , respectively (mean ± SD). Regional analysis showed excellent agreement between Flow O and K 1F at low flow and a significant underestimation of flow by K 1F relative to Flow O in regions of normal and elevated flow. The observed relationship between parameters followed the Renkin‐Crone distribution. The permeability‐surface product was determined as 0.25 minute −1 for vertebral bodies consisting of a mixture of trabecular and cortical bone. We conclude that [ 18 F]fluoride ion PET can be used to estimate bone blood flow in low and normal flow regions, as long as the flow dependency of the E F is taken into consideration. Above blood flow values of 0.2 to 0.35 ml·minute –1 ·ml –1 , the magnitude of K 1F is increasingly independent on blood flow because diffusion limits tracer transport.
Type of Medium:
Online Resource
ISSN:
0884-0431
,
1523-4681
DOI:
10.1359/jbmr.1998.13.8.1328
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
2008867-X
