In:
Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 61, No. 1 ( 2013-01), p. 31-44
Kurzfassung:
We investigated the spatiotemporal expression of vascular endothelial growth factor receptor–3 (VEGFR-3) in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. VEGFR-3 mRNA and protein were constitutively expressed in gray matter neurons and in a few white matter astrocytes. Induction of VEGFR-3 occurred predominantly in perivascular infiltrated macrophages in the spinal cord white matter during the inductive phase of EAE. VEGFR-3 expression was also induced in activated microglial cells in the gray and white matter, mainly in the peak phase. In addition, reactive astrocytes in the white matter, but not in the gray matter, expressed VEGFR-3 as disease severity increased. These data suggest that VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during EAE.
Materialart:
Online-Ressource
ISSN:
0022-1554
,
1551-5044
DOI:
10.1369/0022155412462975
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2013
ZDB Id:
1421306-0
SSG:
12