In:
PLOS Biology, Public Library of Science (PLoS), Vol. 19, No. 9 ( 2021-9-7), p. e3001352-
Abstract:
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated interferon-stimulated genes (ISGs), which encode antiviral proteins, have distinctive nucleotide compositions. We propose that self-targeting by antiviral effectors has selected for ISG transcripts that occupy a less self-targeted sequence space. Following interferon (IFN) stimulation, the CpG-targeting antiviral effector zinc-finger antiviral protein (ZAP) reduces the mRNA abundance of multiple host transcripts, providing a mechanistic explanation for the repression of many (but not all) interferon-repressed genes (IRGs). Notably, IRGs tend to be relatively CpG rich. In contrast, highly upregulated ISGs tend to be strongly CpG suppressed. Thus, ZAP is an example of an effector that has not only selected compositional biases in viral genomes but also appears to have notably shaped the composition of host transcripts in the vertebrate interferome.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001352
DOI:
10.1371/journal.pbio.3001352.g001
DOI:
10.1371/journal.pbio.3001352.g002
DOI:
10.1371/journal.pbio.3001352.g003
DOI:
10.1371/journal.pbio.3001352.g004
DOI:
10.1371/journal.pbio.3001352.g005
DOI:
10.1371/journal.pbio.3001352.s001
DOI:
10.1371/journal.pbio.3001352.s002
DOI:
10.1371/journal.pbio.3001352.s003
DOI:
10.1371/journal.pbio.3001352.s004
DOI:
10.1371/journal.pbio.3001352.s005
DOI:
10.1371/journal.pbio.3001352.s006
DOI:
10.1371/journal.pbio.3001352.s007
DOI:
10.1371/journal.pbio.3001352.s008
DOI:
10.1371/journal.pbio.3001352.s009
DOI:
10.1371/journal.pbio.3001352.s010
DOI:
10.1371/journal.pbio.3001352.s011
DOI:
10.1371/journal.pbio.3001352.s012
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2126773-X