In:
PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 11 ( 2022-11-1), p. e3001838-
Abstract:
Host-associated microbiotas guide the trajectory of developmental programs, and altered microbiota composition is linked to neurodevelopmental conditions such as autism spectrum disorder. Recent work suggests that microbiotas modulate behavioral phenotypes associated with these disorders. We discovered that the zebrafish microbiota is required for normal social behavior and reveal a molecular pathway linking the microbiota, microglial remodeling of neural circuits, and social behavior in this experimentally tractable model vertebrate. Examining neuronal correlates of behavior, we found that the microbiota restrains neurite complexity and targeting of forebrain neurons required for normal social behavior and is necessary for localization of forebrain microglia, brain-resident phagocytes that remodel neuronal arbors. The microbiota also influences microglial molecular functions, including promoting expression of the complement signaling pathway and the synaptic remodeling factor c1q . Several distinct bacterial taxa are individually sufficient for normal microglial and neuronal phenotypes, suggesting that host neuroimmune development is sensitive to a feature common among many bacteria. Our results demonstrate that the microbiota influences zebrafish social behavior by stimulating microglial remodeling of forebrain circuits during early neurodevelopment and suggest pathways for new interventions in multiple neurodevelopmental disorders.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001838
DOI:
10.1371/journal.pbio.3001838.g001
DOI:
10.1371/journal.pbio.3001838.g002
DOI:
10.1371/journal.pbio.3001838.g003
DOI:
10.1371/journal.pbio.3001838.g004
DOI:
10.1371/journal.pbio.3001838.g005
DOI:
10.1371/journal.pbio.3001838.g006
DOI:
10.1371/journal.pbio.3001838.g007
DOI:
10.1371/journal.pbio.3001838.s001
DOI:
10.1371/journal.pbio.3001838.s002
DOI:
10.1371/journal.pbio.3001838.s003
DOI:
10.1371/journal.pbio.3001838.s004
DOI:
10.1371/journal.pbio.3001838.s005
DOI:
10.1371/journal.pbio.3001838.s006
DOI:
10.1371/journal.pbio.3001838.s007
DOI:
10.1371/journal.pbio.3001838.s008
DOI:
10.1371/journal.pbio.3001838.s009
DOI:
10.1371/journal.pbio.3001838.s010
DOI:
10.1371/journal.pbio.3001838.s011
DOI:
10.1371/journal.pbio.3001838.s012
DOI:
10.1371/journal.pbio.3001838.s013
DOI:
10.1371/journal.pbio.3001838.s014
DOI:
10.1371/journal.pbio.3001838.s015
DOI:
10.1371/journal.pbio.3001838.s016
DOI:
10.1371/journal.pbio.3001838.s017
DOI:
10.1371/journal.pbio.3001838.s018
DOI:
10.1371/journal.pbio.3001838.r001
DOI:
10.1371/journal.pbio.3001838.r002
DOI:
10.1371/journal.pbio.3001838.r003
DOI:
10.1371/journal.pbio.3001838.r004
DOI:
10.1371/journal.pbio.3001838.r005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2126773-X
