In:
PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 12 ( 2022-12-1), p. e3001912-
Kurzfassung:
The assimilation, incorporation, and metabolism of sulfur is a fundamental process across all domains of life, yet how cells deal with varying sulfur availability is not well understood. We studied an unresolved conundrum of sulfur fixation in yeast, in which organosulfur auxotrophy caused by deletion of the homocysteine synthase Met17p is overcome when cells are inoculated at high cell density. In combining the use of self-establishing metabolically cooperating (SeMeCo) communities with proteomic, genetic, and biochemical approaches, we discovered an uncharacterized gene product YLL058Wp, herein named Hydrogen Sulfide Utilizing-1 ( HSU1 ). Hsu1p acts as a homocysteine synthase and allows the cells to substitute for Met17p by reassimilating hydrosulfide ions leaked from met17Δ cells into O-acetyl-homoserine and forming homocysteine. Our results show that cells can cooperate to achieve sulfur fixation, indicating that the collective properties of microbial communities facilitate their basic metabolic capacity to overcome sulfur limitation.
Materialart:
Online-Ressource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001912
DOI:
10.1371/journal.pbio.3001912.g001
DOI:
10.1371/journal.pbio.3001912.g002
DOI:
10.1371/journal.pbio.3001912.g003
DOI:
10.1371/journal.pbio.3001912.g004
DOI:
10.1371/journal.pbio.3001912.s001
DOI:
10.1371/journal.pbio.3001912.s002
DOI:
10.1371/journal.pbio.3001912.s003
DOI:
10.1371/journal.pbio.3001912.s004
DOI:
10.1371/journal.pbio.3001912.s005
DOI:
10.1371/journal.pbio.3001912.s006
DOI:
10.1371/journal.pbio.3001912.s007
DOI:
10.1371/journal.pbio.3001912.s008
DOI:
10.1371/journal.pbio.3001912.s009
DOI:
10.1371/journal.pbio.3001912.s010
DOI:
10.1371/journal.pbio.3001912.s011
DOI:
10.1371/journal.pbio.3001912.r001
DOI:
10.1371/journal.pbio.3001912.r002
DOI:
10.1371/journal.pbio.3001912.r003
DOI:
10.1371/journal.pbio.3001912.r004
DOI:
10.1371/journal.pbio.3001912.r005
DOI:
10.1371/journal.pbio.3001912.r006
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2126773-X