In:
PLOS Biology, Public Library of Science (PLoS), Vol. 21, No. 3 ( 2023-3-14), p. e3002031-
Kurzfassung:
Obsessive-compulsive disorder (OCD) and pathological gambling (PG) are accompanied by deficits in behavioural flexibility. In reinforcement learning, this inflexibility can reflect asymmetric learning from outcomes above and below expectations. In alternative frameworks, it reflects perseveration independent of learning. Here, we examine evidence for asymmetric reward-learning in OCD and PG by leveraging model-based functional magnetic resonance imaging (fMRI). Compared with healthy controls (HC), OCD patients exhibited a lower learning rate for worse-than-expected outcomes, which was associated with the attenuated encoding of negative reward prediction errors in the dorsomedial prefrontal cortex and the dorsal striatum. PG patients showed higher and lower learning rates for better- and worse-than-expected outcomes, respectively, accompanied by higher encoding of positive reward prediction errors in the anterior insula than HC. Perseveration did not differ considerably between the patient groups and HC. These findings elucidate the neural computations of reward-learning that are altered in OCD and PG, providing a potential account of behavioural inflexibility in those mental disorders.
Materialart:
Online-Ressource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3002031
DOI:
10.1371/journal.pbio.3002031.g001
DOI:
10.1371/journal.pbio.3002031.g002
DOI:
10.1371/journal.pbio.3002031.g003
DOI:
10.1371/journal.pbio.3002031.g004
DOI:
10.1371/journal.pbio.3002031.g005
DOI:
10.1371/journal.pbio.3002031.g006
DOI:
10.1371/journal.pbio.3002031.s001
DOI:
10.1371/journal.pbio.3002031.s002
DOI:
10.1371/journal.pbio.3002031.s003
DOI:
10.1371/journal.pbio.3002031.s004
DOI:
10.1371/journal.pbio.3002031.s005
DOI:
10.1371/journal.pbio.3002031.s006
DOI:
10.1371/journal.pbio.3002031.s007
DOI:
10.1371/journal.pbio.3002031.s008
DOI:
10.1371/journal.pbio.3002031.s009
DOI:
10.1371/journal.pbio.3002031.s010
DOI:
10.1371/journal.pbio.3002031.s011
DOI:
10.1371/journal.pbio.3002031.s012
DOI:
10.1371/journal.pbio.3002031.s013
DOI:
10.1371/journal.pbio.3002031.s014
DOI:
10.1371/journal.pbio.3002031.s015
DOI:
10.1371/journal.pbio.3002031.s016
DOI:
10.1371/journal.pbio.3002031.s017
DOI:
10.1371/journal.pbio.3002031.s018
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
2126773-X