In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2021-4-15), p. e1009465-
Abstract:
How temperature determines sex remains unknown. A recent hypothesis proposes that conserved cellular mechanisms (calcium and redox; ‘CaRe’ status) sense temperature and identify genes and regulatory pathways likely to be involved in driving sexual development. We take advantage of the unique sex determining system of the model organism, Pogona vitticeps , to assess predictions of this hypothesis. P . vitticeps has ZZ male: ZW female sex chromosomes whose influence can be overridden in genetic males by high temperatures, causing male-to-female sex reversal. We compare a developmental transcriptome series of ZWf females and temperature sex reversed ZZf females. We demonstrate that early developmental cascades differ dramatically between genetically driven and thermally driven females, later converging to produce a common outcome (ovaries). We show that genes proposed as regulators of thermosensitive sex determination play a role in temperature sex reversal. Our study greatly advances the search for the mechanisms by which temperature determines sex.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009465
DOI:
10.1371/journal.pgen.1009465.g001
DOI:
10.1371/journal.pgen.1009465.g002
DOI:
10.1371/journal.pgen.1009465.g003
DOI:
10.1371/journal.pgen.1009465.g004
DOI:
10.1371/journal.pgen.1009465.g005
DOI:
10.1371/journal.pgen.1009465.g006
DOI:
10.1371/journal.pgen.1009465.g007
DOI:
10.1371/journal.pgen.1009465.t001
DOI:
10.1371/journal.pgen.1009465.s001
DOI:
10.1371/journal.pgen.1009465.s002
DOI:
10.1371/journal.pgen.1009465.s003
DOI:
10.1371/journal.pgen.1009465.s004
DOI:
10.1371/journal.pgen.1009465.s005
DOI:
10.1371/journal.pgen.1009465.s006
DOI:
10.1371/journal.pgen.1009465.s007
DOI:
10.1371/journal.pgen.1009465.s008
DOI:
10.1371/journal.pgen.1009465.s009
DOI:
10.1371/journal.pgen.1009465.s010
DOI:
10.1371/journal.pgen.1009465.s011
DOI:
10.1371/journal.pgen.1009465.s012
DOI:
10.1371/journal.pgen.1009465.s013
DOI:
10.1371/journal.pgen.1009465.s014
DOI:
10.1371/journal.pgen.1009465.s015
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2