In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2021-10-13), p. e1009834-
Abstract:
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the Drosophila homolog of Regulator of Telomere Elongation Helicase 1, as a novel regulator of male germline stem cells (GSCs). Our genome-wide transcriptome analysis and ChIP-Seq results suggest that dRTEL1 affects a set of candidate genes required for GSC maintenance, likely independent of its role in DNA repair. Furthermore, dRTEL1 prevents DNA damage-induced checkpoint activation in GSCs. Finally, dRTEL1 functions to sustain Stat92E protein levels, the key player in GSC maintenance. Together, our findings reveal an intrinsic role of the DNA helicase dRTEL1 in maintaining male GSC and provide insight into the function of dRTEL1.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009834
DOI:
10.1371/journal.pgen.1009834.g001
DOI:
10.1371/journal.pgen.1009834.g002
DOI:
10.1371/journal.pgen.1009834.g003
DOI:
10.1371/journal.pgen.1009834.g004
DOI:
10.1371/journal.pgen.1009834.g005
DOI:
10.1371/journal.pgen.1009834.g006
DOI:
10.1371/journal.pgen.1009834.g007
DOI:
10.1371/journal.pgen.1009834.g008
DOI:
10.1371/journal.pgen.1009834.s001
DOI:
10.1371/journal.pgen.1009834.s002
DOI:
10.1371/journal.pgen.1009834.s003
DOI:
10.1371/journal.pgen.1009834.s004
DOI:
10.1371/journal.pgen.1009834.s005
DOI:
10.1371/journal.pgen.1009834.s006
DOI:
10.1371/journal.pgen.1009834.s007
DOI:
10.1371/journal.pgen.1009834.s008
DOI:
10.1371/journal.pgen.1009834.s009
DOI:
10.1371/journal.pgen.1009834.s010
DOI:
10.1371/journal.pgen.1009834.s011
DOI:
10.1371/journal.pgen.1009834.s012
DOI:
10.1371/journal.pgen.1009834.s013
DOI:
10.1371/journal.pgen.1009834.s014
DOI:
10.1371/journal.pgen.1009834.s015
DOI:
10.1371/journal.pgen.1009834.s016
DOI:
10.1371/journal.pgen.1009834.s017
DOI:
10.1371/journal.pgen.1009834.r001
DOI:
10.1371/journal.pgen.1009834.r002
DOI:
10.1371/journal.pgen.1009834.r003
DOI:
10.1371/journal.pgen.1009834.r004
DOI:
10.1371/journal.pgen.1009834.r005
DOI:
10.1371/journal.pgen.1009834.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2