In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2021-11-8), p. e0009869-
Abstract:
Vancomycin-resistant enterococci infection is a worrying worldwide clinical problem. To evaluate the accuracy of GeneXpert vanA/vanB in the diagnosis of VRE, we conducted a systematic review in the study. Methods Experimental data were extracted from publications until May 03 2021 related to the diagnostic accuracy of GeneXpert vanA/vanB for VRE in PubMed, Embase, Web of Science and the Cochrane Library. The accuracy of GeneXpert vanA/vanB for VRE was evaluated using summary receiver to operate characteristic curve, pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. Results 8 publications were divided into 3 groups according to two golden standard references, vanA and vanB group, vanA group, vanB group, including 6 researches, 5 researches and 5 researches, respectively. The pooled sensitivity and specificity of group vanA and vanB were 0.96 (95% CI, 0.93–0.98) and 0.90 (95% CI, 0.88–0.91) respectively. The DOR was 440.77 (95% CI, 37.92–5123.55). The pooled sensitivity and specificity of group vanA were 0.86 (95% CI, 0.81–0.90) and 0.99 (95% CI, 0.99–0.99) respectively, and those of group vanB were 0.85 (95% CI, 0.63–0.97) and 0.82 (95% CI, 0.80–0.83) respectively. Conclusion GeneXpert vanA/vanB can diagnose VRE with high-accuracy and shows greater accuracy in diagnosing vanA .
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009869
DOI:
10.1371/journal.pntd.0009869.g001
DOI:
10.1371/journal.pntd.0009869.g002
DOI:
10.1371/journal.pntd.0009869.g003
DOI:
10.1371/journal.pntd.0009869.g004
DOI:
10.1371/journal.pntd.0009869.g005
DOI:
10.1371/journal.pntd.0009869.g006
DOI:
10.1371/journal.pntd.0009869.t001
DOI:
10.1371/journal.pntd.0009869.t002
DOI:
10.1371/journal.pntd.0009869.t003
DOI:
10.1371/journal.pntd.0009869.s001
DOI:
10.1371/journal.pntd.0009869.s002
DOI:
10.1371/journal.pntd.0009869.s003
DOI:
10.1371/journal.pntd.0009869.s004
DOI:
10.1371/journal.pntd.0009869.s005
DOI:
10.1371/journal.pntd.0009869.s006
DOI:
10.1371/journal.pntd.0009869.r001
DOI:
10.1371/journal.pntd.0009869.r002
DOI:
10.1371/journal.pntd.0009869.r003
DOI:
10.1371/journal.pntd.0009869.r004
DOI:
10.1371/journal.pntd.0009869.r005
DOI:
10.1371/journal.pntd.0009869.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5