In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2023-4-20), p. e0010384-
Abstract:
We describe the results of a prospective observational study of the clinical natural history of human monkeypox (mpox) virus (MPXV) infections at the remote L’Hopital General de Reference de Kole (Kole hospital), the rainforest of the Congo River basin of the Democratic Republic of the Congo (DRC) from March 2007 until August 2011. The research was conducted jointly by the Institute National de Recherche Biomedical (INRB) and the US Army Medical Research Institute of Infectious Diseases (USAMRIID). The Kole hospital was one of the two previous WHO Mpox study sites (1981–1986). The hospital is staffed by a Spanish Order of Catholic Nuns from La Congregation Des Soeurs Missionnaires Du Christ Jesus including two Spanish physicians, who were members of the Order as well, were part of the WHO study on human mpox. Of 244 patients admitted with a clinical diagnosis of MPXV infection, 216 were positive in both the Pan-Orthopox and MPXV specific PCR. The cardinal observations of these 216 patients are summarized in this report. There were three deaths (3/216) among these hospitalized patients; fetal death occurred in 3 of 4 patients who were pregnant at admission, with the placenta of one fetus demonstrating prominent MPXV infection of the chorionic villi. The most common complaints were rash (96.8%), malaise (85.2%), sore throat (78.2%), and lymphadenopathy/adenopathy (57.4%). The most common physical exam findings were mpox rash (99.5%) and lymphadenopathy (98.6%). The single patient without the classic mpox rash had been previously vaccinated against smallpox. Age group of less than 5 years had the highest lesion count. Primary household cases tended to have higher lesion counts than secondary or later same household cases. Of the 216 patients, 200 were tested for IgM & IgG antibodies (Abs) to Orthopoxviruses. All 200 patients had anti-orthopoxvirus IgG Abs; whereas 189/200 were positive for IgM. Patients with hypoalbuminemia had a high risk of severe disease. Patients with fatal disease had higher maximum geometric mean values than survivors for the following variables, respectively: viral DNA in blood (DNAemia); maximum lesion count; day of admission mean AST and ALT.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010384
DOI:
10.1371/journal.pntd.0010384.g001
DOI:
10.1371/journal.pntd.0010384.g002
DOI:
10.1371/journal.pntd.0010384.g003
DOI:
10.1371/journal.pntd.0010384.g004
DOI:
10.1371/journal.pntd.0010384.g005
DOI:
10.1371/journal.pntd.0010384.g006
DOI:
10.1371/journal.pntd.0010384.g007
DOI:
10.1371/journal.pntd.0010384.g008
DOI:
10.1371/journal.pntd.0010384.t001
DOI:
10.1371/journal.pntd.0010384.t002
DOI:
10.1371/journal.pntd.0010384.t003
DOI:
10.1371/journal.pntd.0010384.t004
DOI:
10.1371/journal.pntd.0010384.t005
DOI:
10.1371/journal.pntd.0010384.t006
DOI:
10.1371/journal.pntd.0010384.t007
DOI:
10.1371/journal.pntd.0010384.t008
DOI:
10.1371/journal.pntd.0010384.t009
DOI:
10.1371/journal.pntd.0010384.s001
DOI:
10.1371/journal.pntd.0010384.s002
DOI:
10.1371/journal.pntd.0010384.s003
DOI:
10.1371/journal.pntd.0010384.s004
DOI:
10.1371/journal.pntd.0010384.s005
DOI:
10.1371/journal.pntd.0010384.s006
DOI:
10.1371/journal.pntd.0010384.s007
DOI:
10.1371/journal.pntd.0010384.s008
DOI:
10.1371/journal.pntd.0010384.s009
DOI:
10.1371/journal.pntd.0010384.s010
DOI:
10.1371/journal.pntd.0010384.s011
DOI:
10.1371/journal.pntd.0010384.s012
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2429704-5
