In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2022-10-5), p. e0010742-
Abstract:
Previous studies suggest a relationship between precipitation and ocular toxoplasmosis (OT) reactivation and congenital toxoplasmosis infection. We aimed to investigate the relationship between precipitation and the frequency of new OT cases in Colombia from 2015 to 2019. Methodology This retrospective cohort study analyzed data obtained from a claims-based database created by the Colombian Ministry of Health and national registries of precipitation of the Institute of Hydrology, Meteorology, and Environmental Studies. We estimated the daily number of OT cases, interpolating data from the average number of annual cases from 2015 to 2019. Then, we compared exposures (mean daily precipitation) in the case period in which the events (interpolated OT new cases) occurred by a quasi-Poisson regression, combined with a distributed lag non-linear model to estimate the non-linear and lag–response curve. Principal findings In the 5-year analysis, there were 1,741 new OT cases. Most of the cases occurred in 2019, followed by 2015 and 2018. New OT cases among departments were significantly different ( P 〈 0.01). The cumulative exposure-response curve was decreasing for most departments. Nevertheless, in Chocó, Bogotá, Cesar, Cauca, and Guajira, when a certain amount of precipitation accumulates, the relative risk (RR) increases, which was contrary to the pattern observed in the other regions. The response curves to the one-day lag showed that precipitation influences the RR; however, the trends vary by department. Finally, an increasing trend in the number of cases was directly proportional to precipitation in Guajira, Atlántico, Norte de Santander, Santander, Caquetá and Quindío (r = 0.84; P 〈 0.05). Conclusions Precipitation influenced the RR for new OT cases. However, varying trends among geographical regions (departments) lead us to hypothesize that other sociodemographic, behavioral, and environmental variables, such as wind and water contamination, could influence the RR.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010742
DOI:
10.1371/journal.pntd.0010742.g001
DOI:
10.1371/journal.pntd.0010742.g002
DOI:
10.1371/journal.pntd.0010742.g003
DOI:
10.1371/journal.pntd.0010742.g004
DOI:
10.1371/journal.pntd.0010742.g005
DOI:
10.1371/journal.pntd.0010742.t001
DOI:
10.1371/journal.pntd.0010742.t002
DOI:
10.1371/journal.pntd.0010742.s001
DOI:
10.1371/journal.pntd.0010742.s002
DOI:
10.1371/journal.pntd.0010742.s003
DOI:
10.1371/journal.pntd.0010742.s004
DOI:
10.1371/journal.pntd.0010742.r001
DOI:
10.1371/journal.pntd.0010742.r002
DOI:
10.1371/journal.pntd.0010742.r003
DOI:
10.1371/journal.pntd.0010742.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
