In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2023-8-28), p. e0011584-
Abstract:
There is a lack of systematic evidence for strategies to control loiasis transmission in highly endemic regions. Here we assessed albendazole and ivermectin based treatment regimens to reduce Loa loa microfilaraemia in Gabon. Methods Eligible adult patients with L . loa microfilaraemia between 5,000 and 50,000 microfilariae/ml were randomized to either a control or one of three intervention groups (1:2:2:2 allocation ratio) consisting of three-week twice daily 400mg oral albendazole followed by 1) no treatment, 2) two further weeks of twice daily 400mg albendazole, or 3) a single dose of ivermectin in this open label randomized assessor blinded controlled clinical trial. The primary outcome was the proportion of participants with L . loa microfilaraemia ≤ 100 mf/ml at Day 168. Results In the efficacy-population of 42 patients 0 (0%; control group), 1 (9%; 3-week albendazole), 5 (39%; 5-weeks albendazole) and 2 (22%; 3-week albendazole plus single dose ivermectin) participants met the primary outcome of microfilaraemia below 100/ml at day 168. A 80–90% reduction of microfilaraemia was observed in the active treatment groups. Conclusion The 5-week regimen of albendazole or a 3-week regimen of albendazole followed by ivermectin were most efficacious to reduce microfilaraemia. All therapeutic regimens were well tolerated and safe. Trial registration Trial registered at the Pan-African Clinical Trials Registry: PACTR201807197019027 .
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0011584
DOI:
10.1371/journal.pntd.0011584.g001
DOI:
10.1371/journal.pntd.0011584.g002
DOI:
10.1371/journal.pntd.0011584.t001
DOI:
10.1371/journal.pntd.0011584.t002
DOI:
10.1371/journal.pntd.0011584.t003
DOI:
10.1371/journal.pntd.0011584.t004
DOI:
10.1371/journal.pntd.0011584.t005
DOI:
10.1371/journal.pntd.0011584.t006
DOI:
10.1371/journal.pntd.0011584.s001
DOI:
10.1371/journal.pntd.0011584.s002
DOI:
10.1371/journal.pntd.0011584.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2429704-5