In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2020-11-18), p. e0241659-
Abstract:
The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity. A total of 115 patients with confirmed COVID-19 from a tertiary hospital in Changsha, China, were enrolled. Clinical, laboratory, treatment and outcome data were gathered and compared between patients with and without lymphopenia. The median age was 42 years (1–75). Fifty-four patients (47.0%) of the 115 patients had lymphopenia on admission. More patients in the lymphopenia group had hypertension (30.8% vs. 10.0%, P = 0.006) and coronary heart disease (3.6% vs. 0%, P = 0.029) than in the nonlymphopenia group, and more patients with leukopenia (48.1% vs 14.8%, P 〈 0.001) and eosinopenia (92.6% vs 54.1%, P 〈 0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P 〈 0.001) and C-reactive protein (CRP) level (P = 0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs. 14.0 days, P = 0.002). Lymphocyte recovery appeared the earliest, prior to CRP and chest radiographs, in severe cases, which suggests its predictive value for disease improvement. Our results demonstrated the clinical significance of lymphopenia for predicting the severity of and recovery from COVID-19, which emphasizes the need to dynamically monitor lymphocyte count.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0241659
DOI:
10.1371/journal.pone.0241659.g001
DOI:
10.1371/journal.pone.0241659.g002
DOI:
10.1371/journal.pone.0241659.g003
DOI:
10.1371/journal.pone.0241659.g004
DOI:
10.1371/journal.pone.0241659.g005
DOI:
10.1371/journal.pone.0241659.g006
DOI:
10.1371/journal.pone.0241659.t001
DOI:
10.1371/journal.pone.0241659.s001
DOI:
10.1371/journal.pone.0241659.s002
DOI:
10.1371/journal.pone.0241659.s003
DOI:
10.1371/journal.pone.0241659.s004
DOI:
10.1371/journal.pone.0241659.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3