In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2021-3-12), p. e0248461-
Abstract:
To determine the prognostic significance of long-term adjuvant androgen deprivation therapy (A-ADT) over 1 year in achieving undetectable levels of prostate-specific antigen (PSA) less than 0.001 ng/mL in prostate cancer patients with high- or very high-risk prostate cancer who underwent radiotherapy (RT). Materials and methods A total of 197 patients with prostate cancer received RT, with a follow-up of ≥12 months. Biochemical failure was defined as PSA ≥nadir + 2 ng/mL after RT. We analyzed clinical outcomes, including survival, failure patterns, and prognostic factors affecting outcomes. Results Biochemical failure-free survival (BCFFS), clinical failure-free survival, distant metastasis-free survival, cancer-specific survival, and overall survival (OS) rates at 5 years were 91.1%, 95.4%, 96.9%, 99.5%, and 89.1%, respectively. Administration of long-term A-ADT significantly predicted favorable BCFFS ( p = 0.027) and OS ( p 〈 0.001) in multivariate analysis. Nadir PSA ≤0.001 ng/mL was an independent prognostic factor for BCFFS ( p = 0.006) and OS ( p = 0.021). The use of long-term A-ADT significantly affected nadir PSA ≤0.001 ng/mL ( p 〈 0.001). The patients with A-ADT for 1 year or longer had better BCFFS or OS than those for less than 1 year or those without A-ADT ( p 〈 0.001). The best prognosis was demonstrated in patients treated with long-term A-ADT and nadir PSA ≤0.001 ng/mL in BCFFS ( p 〈 0.001). Conclusion The addition of long-term A-ADT over 1 year to RT demonstrated good treatment outcomes in patients with locally advanced prostate cancer. Achieving a nadir PSA value ≤0.001 ng/mL using combination therapy with RT and A-ADT is a powerful clinical predictor of treatment outcomes.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0248461
DOI:
10.1371/journal.pone.0248461.g001
DOI:
10.1371/journal.pone.0248461.g002
DOI:
10.1371/journal.pone.0248461.g003
DOI:
10.1371/journal.pone.0248461.g004
DOI:
10.1371/journal.pone.0248461.t001
DOI:
10.1371/journal.pone.0248461.t002
DOI:
10.1371/journal.pone.0248461.t003
DOI:
10.1371/journal.pone.0248461.t004
DOI:
10.1371/journal.pone.0248461.s001
DOI:
10.1371/journal.pone.0248461.s002
DOI:
10.1371/journal.pone.0248461.s003
DOI:
10.1371/journal.pone.0248461.r001
DOI:
10.1371/journal.pone.0248461.r002
DOI:
10.1371/journal.pone.0248461.r003
DOI:
10.1371/journal.pone.0248461.r004
DOI:
10.1371/journal.pone.0248461.r005
DOI:
10.1371/journal.pone.0248461.r006
DOI:
10.1371/journal.pone.0248461.r007
DOI:
10.1371/journal.pone.0248461.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
