In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-27), p. e0251992-
Kurzfassung:
Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for COVID-19 vaccine trials. We conducted a survey to evaluate willingness-to-participate in COVID-19 vaccine trials in a population of HCWs at three hospitals in Uganda. Methods The survey was conducted between September and November 2020. Using a standardised questionnaire, data were collected on socio-demographics, previous participation in health research, COVID-19 information sources, underlying health conditions, and willingness-to-participate in COVID-19 vaccine trials. Data were analysed descriptively and a binomial generalised linear model with a log link function used to investigate factors associated with unwillingness to participate. Results 657 HCWs (female, 63%) were enrolled with a mean age of 33 years (Standard Deviation, 10). Overall willingness-to-participate was 70.2%. Key motivating factors for participation were: hope of being protected against COVID-19 (81.1%), altruism (73.3%), and the opportunity to get health care (26.0%). Selected hypothetical trial attributes reduced willingness-to-participate as follows: weekly-quarterly study visits over a 12-month period (70.2%-63.2%, P = 0.026); provision of approximately 50ml of blood at each study visit (70.2%-63.2%, P = 0.026); risk of mild-moderate local adverse reactions (70.2%-60.3%, P 〈 0.001); chance of receiving candidate vaccine or placebo (70.2%-56.9%, P 〈 0.001); and delay of pregnancy [Overall, 70.2%-57.1% P 〈 0.001); Female, 62.8%-48.4% ( P = 0.002); Male, 82.5%-71.5% ( P = 0.003)]. Collectively, these attributes reduced willingness-to-participate from [70.2%-42.2% ( P 〈 0.001) overall; 82.5%-58.1% ( P 〈 0.001) in men; 62.8%-32.6% ( P 〈 0 . 001 ) in women]. Among individuals that were unwilling to participate, the commonest barriers were concerns over vaccine safety (54.6%) and fear of catching SARS-CoV-2 (31.6%). Unwillingness to participate was associated with being female (aRR 1.97, CI 1.46–2.67, P 〈 0.001) and having university or other higher-level education (aRR 1.52, CI 1.05–2.2, P = 0.026). Conclusions Willingness-to-participate in COVID-19 vaccine trials among HCWs in Uganda is high but may be affected by vaccine trial requirements and concerns about the safety of candidate vaccines.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251992
DOI:
10.1371/journal.pone.0251992.t001
DOI:
10.1371/journal.pone.0251992.t002
DOI:
10.1371/journal.pone.0251992.s001
DOI:
10.1371/journal.pone.0251992.s002
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2267670-3
