In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-26), p. e0252026-
Abstract:
To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs’ functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI ( 〉 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI 〉 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0252026
DOI:
10.1371/journal.pone.0252026.g001
DOI:
10.1371/journal.pone.0252026.g002
DOI:
10.1371/journal.pone.0252026.g003
DOI:
10.1371/journal.pone.0252026.g004
DOI:
10.1371/journal.pone.0252026.g005
DOI:
10.1371/journal.pone.0252026.g006
DOI:
10.1371/journal.pone.0252026.t001
DOI:
10.1371/journal.pone.0252026.s001
DOI:
10.1371/journal.pone.0252026.s002
DOI:
10.1371/journal.pone.0252026.s003
DOI:
10.1371/journal.pone.0252026.s004
DOI:
10.1371/journal.pone.0252026.s005
DOI:
10.1371/journal.pone.0252026.s006
DOI:
10.1371/journal.pone.0252026.s007
DOI:
10.1371/journal.pone.0252026.s008
DOI:
10.1371/journal.pone.0252026.s009
DOI:
10.1371/journal.pone.0252026.s010
DOI:
10.1371/journal.pone.0252026.s011
DOI:
10.1371/journal.pone.0252026.s012
DOI:
10.1371/journal.pone.0252026.s013
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3