In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 6 ( 2021-6-10), p. e0252897-
Kurzfassung:
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. There is an urgent need to identify prognostic markers for patients undergoing curative resection of CRC. The detection of circulating tumor cells in peripheral blood is a promising approach to identify high-risk patients with disseminated disease in colorectal cancer. This study aims to evaluate the prognostic relevance of preoperative CTCs using the Cellsearch® system (CS) in patients, who underwent resection with curative intent of different stages (UICC I-IV) of colorectal cancer. Out of 91 Patients who underwent colorectal resection, 68 patients were included in this study. CTC analysis was performed in patients with CRC UICC stages I-IV immediately before surgery. Data were correlated with clinicopathological parameters and patient outcomes. One or more CTCs/7.5 mL were detected in 45.6% (31/68) of patients. CTCs were detected in all stages of the Union of International Cancer Control (UICC), in stage I (1/4, 25%), in stage II (4/12, 33.3%), in stage III (5/19, 26.3%) and in stage IV (21/33, 63.6%). The detection of ≥ 1 CTCs/ 7.5ml correlated to the presence of distant overt metastases (p = 0.014) as well as with shorter progression-free ( p = 0.008) and overall survival ( p = 0.008). Multivariate analyses showed that the detection of ≥ 1 CTCs/ 7.5ml is an independent prognostic indicator for overall survival (HR, 3.14; 95% CI, 1.18–8.32; p = 0.021). The detection of CTCs is an independent and strong prognostic factor in CRC, which might improve the identification of high-risk patients in future clinical trials.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0252897
DOI:
10.1371/journal.pone.0252897.g001
DOI:
10.1371/journal.pone.0252897.g002
DOI:
10.1371/journal.pone.0252897.g003
DOI:
10.1371/journal.pone.0252897.g004
DOI:
10.1371/journal.pone.0252897.t001
DOI:
10.1371/journal.pone.0252897.t002
DOI:
10.1371/journal.pone.0252897.t003
DOI:
10.1371/journal.pone.0252897.s001
DOI:
10.1371/journal.pone.0252897.s002
DOI:
10.1371/journal.pone.0252897.r001
DOI:
10.1371/journal.pone.0252897.r002
DOI:
10.1371/journal.pone.0252897.r003
DOI:
10.1371/journal.pone.0252897.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2267670-3