In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-22), p. e0260204-
Abstract:
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0260204
DOI:
10.1371/journal.pone.0260204.g001
DOI:
10.1371/journal.pone.0260204.g002
DOI:
10.1371/journal.pone.0260204.g003
DOI:
10.1371/journal.pone.0260204.s001
DOI:
10.1371/journal.pone.0260204.s002
DOI:
10.1371/journal.pone.0260204.s003
DOI:
10.1371/journal.pone.0260204.s004
DOI:
10.1371/journal.pone.0260204.s005
DOI:
10.1371/journal.pone.0260204.r001
DOI:
10.1371/journal.pone.0260204.r002
DOI:
10.1371/journal.pone.0260204.r003
DOI:
10.1371/journal.pone.0260204.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
