In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2021-12-3), p. e0261011-
Abstract:
Congenital CMV infection is the first worldwide cause of congenital viral infection but systematic screening of pregnant women and newborns for CMV is still debated in many countries. Objectives This systematic review aims to provide the state of the art on current practices concerning management of maternal and congenital CMV infection during pregnancy, after maternal primary infection (PI) in first trimester of pregnancy. Data sources Electronically searches on databases and hand searches in grey literature. Study eligibility criteria and participants Primary outcome was listing biological, imaging, and therapeutic management interventions in two distinct populations: population 1 are pregnant women with PI, before or without amniocentesis; population 2 are pregnant women with congenitally infected fetuses (after positive amniocentesis). Secondary outcome was pregnancy outcome in population 2. Results Out of 4,134 studies identified, a total of 31 studies were analyzed, with 3,325 pregnant women in population 1 and 1,021 pregnant women in population 2, from 7 countries (Belgium, France, Germany, Israel, Italy, Spain and USA). In population 1, ultrasound (US) examination frequency was 0.75/month, amniocentesis in 82% cases, maternal viremia in 14% and preventive treatment with hyperimmune globulins (HIG) or valaciclovir in respectively 14% and 4% women. In population 2, US examination frequency was 1.5/month, magnetic resonance imaging (MRI) in 44% cases at 32 weeks gestation (WG), fetal blood sampling (FBS) in 24% at 28 WG, and curative treatment with HIG or valaciclovir in respectively 9% and 8% patients. Conclusions This systematic review illustrates management of maternal and congenital CMV during pregnancy in published and non-published literature, in absence of international consensus. Systematic review registration PROSPERO CRD42019124342
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0261011
DOI:
10.1371/journal.pone.0261011.g001
DOI:
10.1371/journal.pone.0261011.g002
DOI:
10.1371/journal.pone.0261011.g003
DOI:
10.1371/journal.pone.0261011.g004
DOI:
10.1371/journal.pone.0261011.t001
DOI:
10.1371/journal.pone.0261011.t002
DOI:
10.1371/journal.pone.0261011.t003
DOI:
10.1371/journal.pone.0261011.s001
DOI:
10.1371/journal.pone.0261011.s002
DOI:
10.1371/journal.pone.0261011.s003
DOI:
10.1371/journal.pone.0261011.s004
DOI:
10.1371/journal.pone.0261011.s005
DOI:
10.1371/journal.pone.0261011.s006
DOI:
10.1371/journal.pone.0261011.s007
DOI:
10.1371/journal.pone.0261011.r001
DOI:
10.1371/journal.pone.0261011.r002
DOI:
10.1371/journal.pone.0261011.r003
DOI:
10.1371/journal.pone.0261011.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3