In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2022-2-8), p. e0263581-
Abstract:
Threatened miscarriages is a common complication of first-trimester pregnancy. Due to the beneficial effects, there are increasing clinical studies on Yunkang oral liquid(YKOL). However, the efficacy and safety of YKOL are still unknown. The aim of this systematic review was to assess the efficacy and safety of YKOL in the treatment of threatened miscarriage during the first-trimester pregnancy (TMFP). Methods This protocol will be prepared according to the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) statement. The systematic review will include all randomized controlled trials (RCTs) studies published until April 2021. Electronic sources including CNKI, WF, VIP, CBM, MEDLINE(PubMed), Embase, Cochrane Library, and Web of Science will be searched for potentially eligible studies. The international clinical trial registration platform and the Chinese clinical trial registration platform of controlled trials will be searched from their inception until April 1st, 2021. According to the inclusion and exclusion criteria, screening literature, extraction data will be conducted by two researchers independently. Statistical analysis will use RevMan 5.3.5 software. The strength of evidence from the studies will be evaluated with the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) methods. Results This study will provide evidence for YKOL combined with conventional therapy for TMFP. Conclusion The efficacy and safety of YKOL combined with conventional therapy for TMFP will be assessed. Systematic review registration INPLASY202140105 ( https://www.doi.org/10.37766/inplasy2021.4.0105 ).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263581
DOI:
10.1371/journal.pone.0263581.g001
DOI:
10.1371/journal.pone.0263581.t001
DOI:
10.1371/journal.pone.0263581.t002
DOI:
10.1371/journal.pone.0263581.s001
DOI:
10.1371/journal.pone.0263581.s002
DOI:
10.1371/journal.pone.0263581.s003
DOI:
10.1371/journal.pone.0263581.s004
DOI:
10.1371/journal.pone.0263581.s005
DOI:
10.1371/journal.pone.0263581.s006
DOI:
10.1371/journal.pone.0263581.s007
DOI:
10.1371/journal.pone.0263581.r001
DOI:
10.1371/journal.pone.0263581.r002
DOI:
10.1371/journal.pone.0263581.r003
DOI:
10.1371/journal.pone.0263581.r004
DOI:
10.1371/journal.pone.0263581.r005
DOI:
10.1371/journal.pone.0263581.r006
DOI:
10.1371/journal.pone.0263581.r007
DOI:
10.1371/journal.pone.0263581.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3