In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2022-2-25), p. e0264351-
Kurzfassung:
Valproic acid (VPA) is a frequently prescribed anti-epileptic drug. Since its introduction side effects on hemostasis are reported. However, studies show conflicting results, and the clinical relevance is questioned. We aimed to determine the coagulopathies induced by VPA in patients who undergo high-risk surgery. The study results warrant attention to this issue, which might contribute to reducing bleeding complications in future patients. Methods Between January 2012 and August 2020, 73 consecutive patients using VPA were retrospectively included. Extensive laboratory hemostatic assessment (including platelet function tests) was performed before elective high-risk surgery. Patient characteristics, details of VPA treatment, and laboratory results were extracted from medical records. Results 46.6% of the patients using VPA (n = 73) showed coagulopathy. Mainly, platelet function disorder was found (36.4%). Thrombocytopenia was seen in 9.6% of the patients. Data suggested that the incidence of coagulopathies was almost twice as high in children as compared to adults and hypofibrinogenemia was only demonstrated in children. No association was found between the incidence of coagulopathies and VPA dosage (mg/kg/day). Conclusion A considerable number of patients using VPA were diagnosed with coagulopathy, especially platelet function disorder. Further prospective studies are needed to confirm the need for comprehensive laboratory testing before elective high-risk surgery in these patients.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0264351
DOI:
10.1371/journal.pone.0264351.g001
DOI:
10.1371/journal.pone.0264351.g002
DOI:
10.1371/journal.pone.0264351.g003
DOI:
10.1371/journal.pone.0264351.t001
DOI:
10.1371/journal.pone.0264351.t002
DOI:
10.1371/journal.pone.0264351.t003
DOI:
10.1371/journal.pone.0264351.t004
DOI:
10.1371/journal.pone.0264351.t005
DOI:
10.1371/journal.pone.0264351.s001
DOI:
10.1371/journal.pone.0264351.s002
DOI:
10.1371/journal.pone.0264351.s003
DOI:
10.1371/journal.pone.0264351.s004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2267670-3