In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2022-9-26), p. e0275013-
Abstract:
Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates ( Na -GST-1 and Na -APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1 H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant changes in few metabolites but only one day after the first vaccination. There was no relationship with immunogenicity. In conclusion, in a small phase 1 trial, urinary metabolomics could distinguish volunteers with different environmental exposures and reflected the safety of the vaccines but did not show a relationship to immunogenicity.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0275013
DOI:
10.1371/journal.pone.0275013.g001
DOI:
10.1371/journal.pone.0275013.g002
DOI:
10.1371/journal.pone.0275013.g003
DOI:
10.1371/journal.pone.0275013.g004
DOI:
10.1371/journal.pone.0275013.s001
DOI:
10.1371/journal.pone.0275013.s002
DOI:
10.1371/journal.pone.0275013.s003
DOI:
10.1371/journal.pone.0275013.s004
DOI:
10.1371/journal.pone.0275013.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3