In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2023-2-24), p. e0282214-
Abstract:
The aim of systematic review and meta-analysis was to investigate whether APOE4 was associated with postoperative neurologic dysfunction occurrence in short- or medium-term among surgical patients and to study the potential genetic association among these two entities. We searched electronic databases for reserch studies to evaluate the association of APOE4 with postoperative delirium (POD) or short- and medium term postoperative cognitive dysfunction (POCD). Twenty-two trials (16 prospective and six retrospective) with 6734 patients were included. APOE4 alleles was shown significantly associated with POCD within 1 week (odds ratio, OR, 1.89, 95% confidence interval, CI, 1.36 to 2.6278, p 〈 0.01) in the random-effects model. A significant association was also noted between APOE4 and POCD in medium-term, 1–3 months, after surgery (OR: 1.67, 95% CI: 1.003–2.839, p = 0.049). However, APOE4 was not significantly associated with POCD 1 year after surgery (OR: 0.98, 95% CI: 0.57–1.70, p = 0.9449) and POD (OR: 1.28, 95% CI: 0.85–1.91, p = 0.23). In conclusion, APOE4 alleles was genetically associated with short- and medium-term postoperative neurological dysfunction and future screening or preventive strategies derived is highly potential to improve outcomes.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282214
DOI:
10.1371/journal.pone.0282214.g001
DOI:
10.1371/journal.pone.0282214.g002
DOI:
10.1371/journal.pone.0282214.g003
DOI:
10.1371/journal.pone.0282214.t001
DOI:
10.1371/journal.pone.0282214.t002
DOI:
10.1371/journal.pone.0282214.t003
DOI:
10.1371/journal.pone.0282214.t004
DOI:
10.1371/journal.pone.0282214.s001
DOI:
10.1371/journal.pone.0282214.s002
DOI:
10.1371/journal.pone.0282214.s003
DOI:
10.1371/journal.pone.0282214.s004
DOI:
10.1371/journal.pone.0282214.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3