In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 9 ( 2023-9-14), p. e0291495-
Kurzfassung:
Considering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signature (actionability), and to collect the treatment modifications based on the CGP test results in clinical practise for solid tumors. Methods This retrospective, multicentre French study was conducted among 25 centres that participated in a free of charge program between 2017 and 2019 for a tissue CGP test. Data were collected on the patient, disease, tumor genomic profile, treatment suggested in the report (related to the genomic profile results) and subsequent therapeutic decisions according to the physician’s declaration. Results Among the 416 patients, most had lung cancer (35.6%), followed by biliary tract cancer (11.5%) or rare cancers (11.1%); 75% had a metastatic disease. The actionability was 75.0% (95% CI [70.6%-78.9%]) for all patients, 85.1% and 78.4%, respectively in lung cancer and metastatic patients. After exclusion of clinical trial suggestions, the actionability decreased to 62.3% (95% CI [57.5%-66.8%] ). Treatment modification based on the test results was observed in 17.3% of the patients and was more frequent in metastatic disease (OR = 2.73, 95% CI [1.31–5.71], p = 0.007). The main reasons for no treatment modification were poor general condition (33.2%) and stable disease or remission (30.2%). The genomic-directed treatment changes were performed mostly during the first six months after the CGP test, and interestingly a substantial part was observed from six to 24 months after the genomic profiling. Conclusion This French study provides information on the real-life actionability of a CGP test based on tissue samples, and trends to confirm its utility in clinical practice across the course of the disease, in particularly for patients with lung cancer and/or advanced disease.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0291495
DOI:
10.1371/journal.pone.0291495.g001
DOI:
10.1371/journal.pone.0291495.g002
DOI:
10.1371/journal.pone.0291495.g003
DOI:
10.1371/journal.pone.0291495.g004
DOI:
10.1371/journal.pone.0291495.t001
DOI:
10.1371/journal.pone.0291495.t002
DOI:
10.1371/journal.pone.0291495.s001
DOI:
10.1371/journal.pone.0291495.s002
DOI:
10.1371/journal.pone.0291495.s003
DOI:
10.1371/journal.pone.0291495.s004
DOI:
10.1371/journal.pone.0291495.s005
DOI:
10.1371/journal.pone.0291495.s006
DOI:
10.1371/journal.pone.0291495.r001
DOI:
10.1371/journal.pone.0291495.r002
DOI:
10.1371/journal.pone.0291495.r003
DOI:
10.1371/journal.pone.0291495.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
2267670-3
