In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 9 ( 2023-9-14), p. e0291521-
Abstract:
The cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microcirculations. We aimed to characterize parameters indicating cerebrovascular reactivity (CVR) and retinal microvascular density in patients with ICA stenosis, and assess if there is correlation between them. Methods In this cross-sectional study the middle cerebral artery (MCA) blood flow velocity was measured by transcranial Doppler (TCD) and, simultaneously, continuous non-invasive arterial blood pressure measurement was performed on the radial artery by applanation tonometry. CVR was assessed based on the response to the common carotid artery compression (CCC) test. The transient hyperemic response ratio (THRR) and cerebral arterial resistance transient hyperemic response ratio (CAR-THRR) were calculated. Optical coherence tomography angiography (OCTA) was used to determine vessel density (VD) on the papilla whole image for all (VDP-WI all ) and for small vessels (VDP-WI small ). The same was done in the peripapillary region: all (VDPP all ), and small (VDPP small ) vessels. The VD of superficial (VDM spf ) and deep (VDM deep ) macula was also determined. Significance was accepted when p 〈 0.05. Results Twenty-four ICA stenotic patients were evaluated. Both CVR and retinal VD were characterized. There was a significant, negative correlation between CAR-THRR (median = -0.40) and VDPP small vessels (median = 52%), as well as between VDPP all vessels (median = 58%), and similar correlation between CAR-THRR and VDP-WI small (median = 49.5%) and between VDP-WI all (median = 55%). Conclusion The significant correlation between impaired cerebrovascular reactivity and retinal vessel density in patients with ICA stenosis suggests a common mechanism of action. We propose that the combined use of these diagnostic tools (TCD and OCTA) helps to better identify patients with increased ischemic or other cerebrovascular risks.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0291521
DOI:
10.1371/journal.pone.0291521.g001
DOI:
10.1371/journal.pone.0291521.g002
DOI:
10.1371/journal.pone.0291521.g003
DOI:
10.1371/journal.pone.0291521.g004
DOI:
10.1371/journal.pone.0291521.t001
DOI:
10.1371/journal.pone.0291521.t002
DOI:
10.1371/journal.pone.0291521.t003
DOI:
10.1371/journal.pone.0291521.s001
DOI:
10.1371/journal.pone.0291521.s002
DOI:
10.1371/journal.pone.0291521.s003
DOI:
10.1371/journal.pone.0291521.s004
DOI:
10.1371/journal.pone.0291521.s005
DOI:
10.1371/journal.pone.0291521.s006
DOI:
10.1371/journal.pone.0291521.s007
DOI:
10.1371/journal.pone.0291521.s008
DOI:
10.1371/journal.pone.0291521.r001
DOI:
10.1371/journal.pone.0291521.r002
DOI:
10.1371/journal.pone.0291521.r003
DOI:
10.1371/journal.pone.0291521.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3