In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2021-2-25), p. e1009310-
Kurzfassung:
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage product released during the synthesis of colibactin, a bacterial genotoxin, in 55 of the samples examined. Uropathogenic Escherichia coli strains isolated from these patients, as well as the archetypal E . coli strain UTI89, were found to produce colibactin. In a murine model of UTI, the machinery producing colibactin was expressed during the early hours of the infection, when intracellular bacterial communities form. We observed extensive DNA damage both in umbrella and bladder progenitor cells. To the best of our knowledge this is the first report of colibactin production in UTIs in humans and its genotoxicity in bladder cells.
Materialart:
Online-Ressource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009310
DOI:
10.1371/journal.ppat.1009310.g001
DOI:
10.1371/journal.ppat.1009310.g002
DOI:
10.1371/journal.ppat.1009310.g003
DOI:
10.1371/journal.ppat.1009310.g004
DOI:
10.1371/journal.ppat.1009310.g005
DOI:
10.1371/journal.ppat.1009310.s001
DOI:
10.1371/journal.ppat.1009310.s002
DOI:
10.1371/journal.ppat.1009310.s003
DOI:
10.1371/journal.ppat.1009310.s004
DOI:
10.1371/journal.ppat.1009310.s005
DOI:
10.1371/journal.ppat.1009310.s006
DOI:
10.1371/journal.ppat.1009310.s007
DOI:
10.1371/journal.ppat.1009310.s008
DOI:
10.1371/journal.ppat.1009310.s009
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2205412-1
