In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2022-8-31), p. e1010726-
Kurzfassung:
Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however, the stabilities of clones of infected T cells in persons on long-term ART are not well defined. We determined the relative stabilities of clones of infected and uninfected CD4+ T cells over time intervals of one to four years in three individuals who had been on ART for 9–19 years. The largest clones of uninfected T cells were larger than the largest clones of infected T cells. Clones of infected CD4+ T cells were more stable than clones of uninfected CD4+ T cells of a similar size. Individual clones of CD4+ T cells carrying intact, infectious proviruses can expand, contract, or remain stable over time.
Materialart:
Online-Ressource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1010726
DOI:
10.1371/journal.ppat.1010726.g001
DOI:
10.1371/journal.ppat.1010726.g002
DOI:
10.1371/journal.ppat.1010726.g003
DOI:
10.1371/journal.ppat.1010726.t001
DOI:
10.1371/journal.ppat.1010726.t002
DOI:
10.1371/journal.ppat.1010726.t003
DOI:
10.1371/journal.ppat.1010726.t004
DOI:
10.1371/journal.ppat.1010726.s001
DOI:
10.1371/journal.ppat.1010726.s002
DOI:
10.1371/journal.ppat.1010726.s003
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2205412-1