In:
American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. 8 ( 2021-08), p. 1741-1745
Abstract:
The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified. METHODS: We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years. Results: While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths. Discussion: Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.
Type of Medium:
Online Resource
ISSN:
0002-9270
,
1572-0241
DOI:
10.14309/ajg.0000000000001326
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021