In:
American Society of Clinical Oncology Educational Book, American Society of Clinical Oncology (ASCO), , No. 33 ( 2013-05), p. 15-23
Abstract:
KEY POINTS Next-generation sequencing (NGS) refers to not only evaluation of gene expression, but also DNA single nucleotide variants, small insertions and deletions, structural alterations, and copy number alterations. When applied to RNA, NGS provides information on expression levels, alternatively spliced isoforms, mutant transcripts, and novel transcripts arising from fusion genes. NGS has facilitated more refined disease classification and target discovery. PIK3CA and TP53 are the most commonly mutated genes that vary in frequency by intrinsic subtype. Clinical application of NGS for therapeutic targeting is currently limited by a dearth of available drugs targeting actionable alterations.
Type of Medium:
Online Resource
ISSN:
1548-8748
,
1548-8756
DOI:
10.14694/EdBook_AM.2013.33.15
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2431126-1
