In:
jpme, Walter de Gruyter GmbH, Vol. 37, No. 6 ( 2009-11-01), p. 673-676
Kurzfassung:
We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency (NT) between 11 +0 and 13 +6 weeks' gestation. The aim of this study was to assess the corresponding NT anatomic features by immunohistochemical (IHC) investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin (SMA). We found that all 18 cases were D2-40 positive, CD31 positive, and CD34 negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesis plays a relevant role in nuchal edema, increased NT, and that increased NT is the result of a lymphatic malformation or a delayed development of the lymphatic system.
Materialart:
Online-Ressource
ISSN:
1619-3997
,
0300-5577
DOI:
10.1515/JPM.2009.107
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2009
ZDB Id:
1467968-1