In:
Biological Chemistry, Walter de Gruyter GmbH, Vol. 395, No. 2 ( 2014-02-01), p. 143-149
Kurzfassung:
The capacity of cytoskeletal septins to mediate diverse cellular processes is related to their ability to assemble as distinct heterooligomers and higher order structures. However, in many cell types the functional relevance of septins is not well understood. This minireview provides a brief overview of our current knowledge about septins in the non-neuronal cells of the vertebrate nervous system, collectively termed ‘glial cells’, i.e., astrocytes, microglia, oligodendrocytes, and Schwann cells. The dysregulation of septins observed in various models of myelin pathology is discussed with respect to implications for hereditary neuralgic amyotrophy (HNA) caused by mutations of the human SEPT9 -gene.
Materialart:
Online-Ressource
ISSN:
1437-4315
,
1431-6730
DOI:
10.1515/hsz-2013-0240
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2014
ZDB Id:
1466062-3
SSG:
12
