In:
Journal of Basic and Clinical Physiology and Pharmacology, Walter de Gruyter GmbH, Vol. 27, No. 6 ( 2016-01-1)
Abstract:
Chronic arsenic exposure via contaminated drinking water is a global environmental health problem associated with hematological, hepatic and many serious systemic disorders. This study on adult male rats evaluated the protective effects of vitamin E (VE) and vitamin C (VC) against arsenic-mediated hematological and hepatic toxicities. Methods: Arsenic was administered orally as arsenic trioxide (3 mg/kg body weight/day), as a single dose for 30 consecutive days or along with VC/ascorbic acid (200 mg/kg body weight/day dissolved in water) and VE/α-tocopherol (400 mg/kg body weight/day dissolved in olive oil) as supplements. Multiple hematological and hepatic parameters were assessed. Results: Arsenic exposure caused significant reduction of erythrocyte counts (p 〈 0.05), leukocyte counts (p 〈 0.01) and hemoglobin (Hb) levels (p 〈 0.01). Arsenic exposure also led to marked echinocytic transformation of erythrocytes resulting in increased morphological index (p 〈 0.001). Altered serum oxidative balance was observed with a higher oxidative stress index (p 〈 0.001). The results also showed a significant increase of serum cholesterol (p 〈 0.05), low-density lipoprotein (p 〈 0.001) and triglycerides (p 〈 0.01), and decreased high-density lipoprotein (p 〈 0.01) along with total protein (p 〈 0.01). A marked elevation of hepatic thiobarbituric acid reactive substance (p 〈 0.05) along with decreased reduced glutathione (p 〈 0.001) levels were also observed. Interestingly, co-administration of VC and VE significantly prevented all the arsenic-induced alterations (p 〈 0.05) except Hb content and serum protein. Conclusions: The present investigation offers strong evidence regarding the protective efficacy of co-administration of VC and VE against hematotoxicity and hepatotoxicity in adult male rats caused by chronic arsenic exposure.
Type of Medium:
Online Resource
ISSN:
2191-0286
,
0792-6855
DOI:
10.1515/jbcpp-2016-0020
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2016
detail.hit.zdb_id:
2602428-7
SSG:
15,3
