In:
labm, Walter de Gruyter GmbH, Vol. 37, No. 1 ( 2013-08-09), p. ---
Kurzfassung:
C-reactive protein (CRP) currently constitutes one of the most widely used parameters for the diagnosis of infections and inflammatory processes, due to simple methods and low costs. However, in recent years, other parameters, such as interleukin 6 (IL-6) and procalcitonin (PCT), have gained in importance. Although these parameters are presently not established everywhere in clinical routine, they provide significant advantages in the diagnosis and monitoring of inflammatory diseases. For instance, in intensive care, the increase in IL-6 levels may indicate inflammatory complications 24 to 48 h prior to the increase in circulating CRP levels. In contrast to CRP, PCT shows a higher specifity for bacterial infections, which facilitates the diagnosis of bacterial infections and sepsis. PCT measurements further allow assessment of therapeutic success and indicate necessary changes in antibiotic therapy. These points raise the question whether CRP measurements should at least in part be replaced by PCT and/or IL-6. Thus, this review seeks to examine the value of CRP in relation to PCT and IL-6 for the diagnosis of bacterial infections, in therapeutic monitoring, and regarding prognosis in critical care patients.
Materialart:
Online-Ressource
ISSN:
1439-0477
,
0342-3026
DOI:
10.1515/labmed-2013-0029
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2013
ZDB Id:
2081704-6
ZDB Id:
2909042-8
SSG:
15,3
