In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 33, No. 6 ( 1978-6-1), p. 666-668
Abstract:
In the photolysis of 5-bromouracil containing DNA Br atoms are expected inter mediates. In order to evaluate the possible site of attack of the Br atom at the sugar moiety of DNA the reaction of 2-deoxy-D-ribose with the Br atom (complexed with two bromide ions) was investigated. Hydroxyl radicals generated by the radiolysis of N 2 O saturated aqueous solutions were converted into Br 3 ·2- radicals by 1 M bromide ions. Br 3 ·2- reacts with 2-deoxy-D-ribose (k = 3.7 · 104M -1 s -1 , pulse radiolysis). The major product is 2-deoxy-D-erythro-pentonic acid (G = 2.4, γ-radiolysis). It is formed by hydrogen abstraction from C-l and oxidation of this radical by other radicals. An alternative route via the radical at C-2 is neglible. It follows that Br 3 ·2 - reacts preferentially at C-1 of 2-deoxy-D-ribose
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-1978-0622
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1978
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
