In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 50, No. 11-12 ( 1995-12-1), p. 813-819
Abstract:
In a screening for inhibitors of fungal melanin biosynthesis a novel test system was success fully employed. With this test system, based on the production of dihydroxynaphthalene melanin (DHN melanin) by a Lachnellula species in agar cultures, extracts of cultures of basidiomycetes, ascomycetes and deuteromycetes were tested. From fermentations of Col-lybia dryophila, 6-methylpurine (1) and 6-methyl-9-β-ᴅ-ribofuranosylpurine (2) were isolated as the active principles and 3,5-dichloro-4-methoxybenzoic acid (3) was obtained from cultures of Stropharia squamosa. The corresponding alcohol (4) and aldehyde (5) previously isolated from several basidiomycetes, were also active in this test system. In a screening of fungal metabolites, 1-methoxy-8-hydroxynaphthalene and 1,8-dimethoxynaphthalene inhibited biosynthesis of DHN melanin. Among the inhibitors identified, compounds 3 -5 were the most selective ones. They were the only metabolites without cytotoxic activities.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-1995-11-1212
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1995
detail.hit.zdb_id:
2078107-6
SSG:
12
