In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 67, No. 9-10 ( 2012-10-1), p. 466-472
Kurzfassung:
A series of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]ace tamido] -benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. Their structures were elucidated by spectral techniques. These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drugresistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. The minimum inhibitory concentration (MIC) of each compound was determined by a two-fold serial dilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 32 - 256 μg/ml. Although standard drugs were more active against the pathogenes employed in this study, the activities of the new benzoxazoles and reference drugs against drug-resistant isolates of the microorganisms were largely similar
Materialart:
Online-Ressource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-2012-9-1004
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2012
ZDB Id:
2078107-6
SSG:
12
