In:
The Journal of Neuroscience, Society for Neuroscience, Vol. 31, No. 49 ( 2011-12-07), p. 18180-18184
Kurzfassung:
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
Materialart:
Online-Ressource
ISSN:
0270-6474
,
1529-2401
DOI:
10.1523/JNEUROSCI.4960-11.2011
Sprache:
Englisch
Verlag:
Society for Neuroscience
Publikationsdatum:
2011
ZDB Id:
1475274-8
SSG:
12
