In:
The EMBO Journal, EMBO, Vol. 33, No. 23 ( 2014-12), p. 2765-2781
Kurzfassung:
image The protease activity of MALT 1 is essential for the adaptive immune response, but also for the generation of T reg cells and the prevention of autoimmune gastritis. Mice expressing a catalytically inactive form of M alt1 (Malt1 knock‐in mice) are strongly immunodeficient and have impaired development of marginal zone B cells and B 1 B cells. Malt1 protease activity is required for efficient activation of lymphocytes, NK cells, and dendritic cells by immunoreceptors with ITAM motifs. The absence of M alt1 protease activity protects mice against experimental autoimmune encephalitis and T ‐cell transfer‐induced colitis. The protease activity of M alt1 is also essential for the development of natural regulatory T cells (Tregs). Malt1 knock‐in mice but not M alt1‐deficient mice develop autoimmune gastritis, most likely as a consequence of M alt1 scaffold‐driven immune responses in the absence of efficient T reg functions.
Materialart:
Online-Ressource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201488987
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2014
ZDB Id:
1467419-1
ZDB Id:
586044-1
SSG:
12