In:
The EMBO Journal, EMBO, Vol. 34, No. 23 ( 2015-12-02), p. 2971-2983
Abstract:
image Terminally differentiated somatic cells can be directly converted into induced oligodendrocyte progenitor cells by Oct4‐mediated direct reprogramming strategy. Oct4 can convert somatic cells fate toward iOPC s under defined glial induction culture condition. Oct4‐ iOPC s are self‐renewing and bipotent somatic stem cells that can give rise to both astrocytes and myelinating oligodendrocytes in vitro and in vivo . Oct4‐ iOPC s exhibit the typical characteristics of OPC including similar global gene expression profiles compared to wild‐type OPC s. Transplantation of Oct4‐ iOPC s promotes functional recovery after traumatic spinal cord injury without tumor formation.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201592652
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12