In:
The EMBO Journal, EMBO, Vol. 36, No. 9 ( 2017-05-02), p. 1147-1166
Abstract:
image The linear ubiquitin chain assembly complex ( LUBAC ), known to play key role in various immune receptor pathways, is identified as a crucial regulator of TRAIL ‐induced signalling complexes, restricting apoptosis and necroptosis while promoting cytokine production. TRAIL ‐induced complex I and II both act as death‐inducing and gene‐activatory signalling platforms. LUBAC is recruited to TRAIL complex I downstream of FADD , caspase‐8 and cIAP 1/2, yet independently of RIPK 1. LUBAC is recruited to complex I and II in TRAIL signalling and restricts TRAIL ‐induced necroptosis and apoptosis. LUBAC promotes gene expression and cytokine production by recruiting the IKK complex to TRAIL complexes I and II .
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201695699
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12