In:
The EMBO Journal, EMBO, Vol. 36, No. 18 ( 2017-09-15), p. 2684-2697
Abstract:
image Hi‐C analysis at 15 distinct stages provides a comprehensive map of chromosome dynamics throughout the budding yeast cell cycle. This illustrates how SMC complexes control chromosome looping and suggests that condensin contributes to chromosome segregation during anaphase. Genome‐wide Hi‐C contact maps provide a comprehensive overview of genome reorganization throughout the cell cycle. Three different chromosome folding states, basic (G1), condensed (metaphase) and extended (anaphase), alternate during the cycle. Altered contacts upon microtubule destabilization imply microtubule‐induced stretching in anaphase. Formation of a condensin‐dependent intra‐chromosomal loop during anaphase bridges rDNA with the centromere, possibly through a loop extrusion mechanism.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201797342
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12